The cell viability assay showed that the resistance of K562/G01 cells to imatinib was significantly up-regulated (Fig. 2I), overexpression of KIAA1429 also increase imatinib resistance in the CML IM sensitive cell line K562 and KCL22 (Fig. S1F), suggesting that the increased expression of KIAA1429 may be associated with the imatinib resistance of CML cells. The gene discussed is VIRMA; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.