VIRMA and chronic myelogenous leukemia, BCR-ABL1 positive: To investigate the biological effects of KIAA1429 in CML, a KIAA1429 overexpression plasmid, Lv-KIAA1429, was constructed and used to transfect CML cell lines (K562, K562/G01, and KCL22) (Fig. 2A, B).