GDNF and gastric cancer: Of the six hypermethylated genes (RORA, ADAM23, MLF1, MINT25, GDNF, and PRDM5), GDNF and MINT25 are the most sensitive biomarkers for early GC, and in terms of gastric washes, the MINT25 site has the best specificity (95.8%) and sensitivity (90%).93