Scientific evidence supports the dual functions of miR-205 as a tumor suppressor by affecting ErbB3, VEGFA, and ZEB1/2 in breast, melanoma, and lung cancers, as well as an oncogene by influencing PTEN, TRAF2, and SHIP2 in breast cancer, nasopharyngeal carcinoma, and lung squamous cell carcinoma.108. The gene discussed is PTEN; the disease is breast cancer.