YAP1 and breast carcinoma: miR-30a targets the oncogene YAP, which is frequently dysregulated in breast cancer and is associated with a poor prognosis.65, 66, 67 Researchers discovered a significant inverse association between miR-30a and YAP in MCF-10A cells (as normal) and MDA-MB-231 (as cancerous) cells using Real-Time Quantitative-PCR.