Adiponectin was significantly lower in O+/NAFLD+/DM+ (group 1) as compared with O-/NAFLD+/DM+ (group 2), O+/NAFLD+/DM- (group 3), and control subjects (group 4) (15.2 ± 3.1 vs 26.3 ± 12.1, 37.6 ± 20.5, and 47 ± 11.5 μg/dl, respectively, p  < 0.001) (Table 1). The gene discussed is ADIPOQ; the disease is diabetes mellitus.