Overall, higher exposureto PM10 in the first and second trimester exposure was associated withEV-miRNAs that were enriched in pathways related to cancer, including proteoglycansin cancer, miRNAs in cancer, and p53 signaling pathway (supplemental table 5).EV-miRNAs associated with higher exposure to PM2.5 during the firsttrimester were enriched in pathways including: proteoglycans in cancer, miRNAs incancer, and p53 signaling pathway (supplemental table 6). The gene discussed is TP53; the disease is cancer.