Blood S100B was also elevated in psychosis, with a large effect size (SMD, 0.88; 95% CI, 0.59–1.17; p < 0.001) (32, 35–65), which remained significant after excluding 3 outlier studies (Supplementary Figure S2; SMD, 0.70; 95% CI, 0.44–0.96; p < 0.001) (46, 55, 56). The gene discussed is S100B; the disease is psychotic disorder.