After depletion of DRP1 and FIS1 in cells, RLR signaling increases, and elongation of the mitochondrial network enhances the endoplasmic reticulum (ER)-mitochondria interaction during viral infection and increases the association of MAVS to enhance RLR signaling (Castanier et al., 2010; Kim et al., 2018). The gene discussed is MAVS; the disease is viral infectious disease.