We analyzed the basic physiological and clinical biochemical indictors and found that the indexes of DBP, SBP, D-DI/ PLT, RPR, PLR, NLR, D-DI, PLT, PT, INR, urea, UA, Ccr, BNP, CK-MB, PO2, Lac, SOFA, and NEWS showed significant differences in the sepsis patients between the survival and fatality groups. The gene discussed is NPPB; the disease is Sepsis.