For example, the expression of tumor P2X7R can promote the growth, invasion, and metastasis of tumor cells, while the expression of host P2X7R can trigger a tumor immune response through inflammatory cell infiltration, such as the release of IL‐1β and other inflammatory factors by dendritic cells (DCs) and macrophages, and inhibit tumor progression.187, 188. Here, IL1B is linked to neoplasm.