CDNF and amyotrophic lateral sclerosis: In addition, more recently discovered neurotrophic factors, such as cerebral dopamine neurotrophic factor (CDNF), are being evaluated in preclinical ALS models, and CDNF recently was reported to slow progression of ALS in both Sod1G93A and TardbpM377V mouse models (Lindahl et al., 2017; De Lorenzo et al., 2023).