TNFRSF1A and amyotrophic lateral sclerosis: In a study evaluating the role of the TNFα receptor TNFR1 in the progression of ALS, it was discovered that Tnfr1−/− mice have a more rapidly progressing disease course when crossed into the Sod1G93A line, as compared to Tnfr1+/+; Sod1G93A mice (Brambilla et al., 2016).