PTEN and PTEN hamartoma tumor syndrome: Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is a rare neurocutaneous syndrome caused by germline pathogenic variants of the PTEN tumor suppressor gene (Hendricks et al., 2020; Isik et al., 2020; Kim et al., 2020) that cause an increased risk of developing benign and malignant tumors of the thyroid, breast, endometrium, skin, and brain.