The increased susceptibility to develop hamartomatous polyps in the gastrointestinal tract is also related to uncontrolled cell growth in patients with PTEN mutation, especially subjects with heterozygous PTEN deletions developing intestinal epithelial dysplasia with subsequent invasion of the lamina propria, as described in adenoma-carcinoma progression (Marsh V. et al., 2008). Here, PTEN is linked to adenoma.