Next, we identified that the missense mutation of LUM was the primary type of genetic alteration, and the E240K/* alteration was detected in three cases of SKCM, two cases of COAD, and one case of BRCA, LUAD, STAD, UCEC and Rectal Adenocarcinoma (Figures 3B, C). Here, LUM is linked to rectum adenocarcinoma.