BRAF and neoplasm: BRAFV600E has been widely found in various types of neoplasms, including PTC (Nam et al., 2012; Silver et al., 2021; Eng et al., 2023), and its negative impact on BRAF kinase and the MAPK/ERK pathway is well-known (Cantwell-Dorris et al., 2011; Cohen et al., 2021).