HIF1A and asthma: revealed that the expression level of hypoxia-inducible factor-1α (HIF-1α) and HIF-2α was upregulated in the brain tissue of mice induced with asthma by house dust mites (HDM) along with the decreased synaptic plasticity in the hippocampus, and the learning and memory abilities of asthmatic mice, as measured by the Barnes maze test, were impaired compared with those of the control group (56, 57).