NR3C1 and asthma: Amygdala stimulation further activates the hypothalamic–pituitary–adrenal (HPA) axis, and glucocorticoids are released into the circulation to bind to glucocorticoid receptors (GR) on the surface of the airway epithelium and immune cells as well as to achieve the central regulation of peripheral inflammation, particularly in the expression of cellular inflammatory factors (such as IL-4, IL-5, and IL-13) involved in the development of asthma (12, 40).