CRH and asthma: Additionally, the expression level of type 2 inflammatory factors and corticotropin-releasing hormone was upregulated in the PFC, whereas c-FOS protein was deposited in the hypothalamus and amygdala of OVA-sensitized animal models, in which the activation of the HPA axis by corticotropin-releasing hormone could exacerbate asthma symptoms while modulating negative emotions (68, 75).