identified that the expression level of GR in the lungs of stressed asthmatic mice was drastically downregulated following the activation of the HPA axis, which may be connected to the impaired nuclear translocation of GR in macrophages and other cells, thereby reducing the responsiveness of the body to glucocorticoids, suppressing its anti-inflammatory ability, and deteriorating the airway inflammatory response in patients with asthma (42, 43). This evidence concerns the gene NR3C1 and asthma.