CLOCK and asthma: also discovered a dramatic increase in the number of eosinophils in the blood, the upregulation of the expression level of pro-inflammatory cytokines in the lungs, and a sharp increase in the degree of pulmonary inflammation in OVA-induced asthma in a BMAL1-knockout mouse model, which suggests that the regulation of circadian clock genes on asthma and rhythm may be biphasic (95).