team concluded from observing the changes in the LPS-induced sepsis mice model 24 hours after LPS injection that Sentrin/SUMO-specific protease 3 (SENP3) promotes M1 macrophage polarization and the production of pro-inflammatory cytokines via the hypoxia-inducible factor 1α (HIF-1α)/Pyruvate kinase isozymes M2 (PKM2) axis, thereby contributing to lung injury; hence, SENP3 could represent a potential therapeutic target for LPS-induced ALI treatment (38). The gene discussed is SENP3; the disease is Sepsis.