IGFBP3 and cancer: Indeed, several genes in the m6A-related signature, such as HDAC2, GYS2, and IGFBP3, were previously shown to regulate cancer development in an m6A-dependent manner; IGFBP3 potentially functions as a downstream effector of the YTHDF2-mediated the m6A-MYC axis to promote glioblastoma stem cell growth (31).