Exercise constitutes an essential component in both the prevention and management of lung cancer, with potential underlying biological mechanisms comprising p53-mediated apoptosis, inhibition of lung cancer cell proliferation and survival, augmentation of host immunity, facilitation of immune cell infiltration, refinement of the tumor microenvironment, attenuation of chronic inflammation, activation of DNA repair enzymes, and fortification against oxidative stress (3, 5, 7, 18–24). The gene discussed is TP53; the disease is lung cancer.