The expression of the inhibitory receptor NKG2A and the checkpoint proteins PD1 and CD73 were similar on both NK cells and CD8+ T cells in CTCL and healthy skin, but the immune checkpoint protein LAG3 was downregulated on CTCL NK cells compared to healthy NK cells (Figures 3G–J; Supplementary Figures S4G–J). Here, LAG3 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.