CD8A and neoplasm: To test this hypothesis, we investigated their capacity to produce cytokines crucial for anti-tumor immune responses upon PMA and ionomycin stimulation in vitro. Interestingly, CTCL NK cells, as well as CTCL CD8+ T cells, were able to produce pro-inflammatory IFNγ to the same level as cells derived from healthy skin, indicating normal cytokine secreting capacity.