TGFB1 and neoplasm: Tumor-associated macrophages (TAMs) derive from circulating monocytic precursors, infiltrating macrophages in tumor tissue are driven by tumor-derived cytokines (e.g. IL-10, TGF-β) and T cell-derived cytokines (e.g. IL-4, IL-13) and acquire a polarized M2 phenotype (100).