NFAT5 and colorectal carcinoma: Studies have also found that ETBF plays an important role in promoting CRC through the Toll-like receptor 4 (TLR4)-Nuclear Factor of Activated T-cells 5 (NFAT5)-dependent upregulation of Jumonji domain-containing protein 2B (JMJD2B) levels in stem cell regulation (80, 81).