However, high level of HMGB1 levels may result in female reproductive disorders, including recurrent spontaneous abortion (RSA) (21), gestational diabetes mellitus (GDM) (22), preterm birth (PTB) (23), preeclampsia (PE) (24), polycystic ovary syndrome (PCOS) (25), and endometriosis (26). This evidence concerns the gene HMGB1 and gestational diabetes.