We aim to present a comprehensive landscape of HMGB1’s role across a timeline that begins prior to conception with issues affecting fertility, such as polycystic ovary syndrome and endometriosis, and extends through varying stages of pregnancy, encapsulating pregnancy complications like unexplained recurrent spontaneous abortion, preeclampsia, gestational diabetes mellitus, and preterm birth. This evidence concerns the gene HMGB1 and preeclampsia.