SPP1 and colorectal carcinoma: ROC analysis showed that the AUC values are 0.98, 0.79, 0.92, 0.59 for COLEC11 (p<0.001), CAV1 (p<0.001), SPP1 (p<0.001), and ANGPTL2 (p=0.0062) to differentiate LM-CRC from primary CRC, respectively (Figure 2F).