SPP1 and colorectal carcinoma: Consistently, the gene sets of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION and HALLMARK_UV_RESPONSE_DN are specifically enriched in the ANGPTL2+CAFs in CRC tissues (Figures 6G, H) and the gene sets of HALLMARK_COMPLEMENT and HALLMARK_KRAS_SIGNALING_UP are significantly enriched in the SPP1+macrophages in CRC tissues (Figures 6I, J).