Subsequently, GSEA analysis of scRNA-seq data in the GSE166555 dataset was carried out and the results uncovered that compared to other identified cell types, the gene sets of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION and HALLMARK_UV_RESPONSE_DN are specifically enriched in the ANGPTL2+CAFs of CRC tissues (Figures 6C, D). The gene discussed is ANGPTL2; the disease is colorectal carcinoma.