SPP1 and colorectal carcinoma: The cell-cell interaction (CCI) analysis revealed that ANGPTL2+CAFs mainly interact with malignant CRC cells, mono/macrophages, epithelial cells, and dendritic cells (DCs) (Figure 4F) and that SPP1+macrophages mainly interact with malignant CRC cells, endothelial cells, DCs, proliferating T cells, and myofibroblasts (Figure 4G).