ROC analysis of the GSE49355 dataset showed that the AUC values are 0.96, 0.91, 0.88, 0.83 for COLEC11 (p<0.001), CAV1 (p<0.001), SPP1 (p<0.001), and ANGPTL2 (p<0.001) to differentiate LM-CRC from primary CRC, respectively (Figure 2D). This evidence concerns the gene SPP1 and colorectal carcinoma.