ROC analysis of the GSE81558 dataset showed that the AUC values are 0.98, 0.84, 0.72, 0.81 for COLEC11 (p<0.001), CAV1 (p<0.001), SPP1 (p=0.015), and ANGPTL2 (p<0.001) to differentiate LM-CRC from primary CRC, respectively (Figure 2E). This evidence concerns the gene ANGPTL2 and colorectal carcinoma.