The most common immune-related adverse events were pruritus (24%), hypothyroidism (16%), increased bilirubin (16%), and ALT increase (16%) in group A. The major (grade 3–4) immune-related adverse events were hypothyroidism (8%), ALT increased (4%), and colitis (4%) in group A, which was resolved after the treatment with a corticosteroid. This evidence concerns the gene GPT and colitis.