In this study, nine FARGs (ACTB, CCND, MAP2K1, MAPK9, PARVB, PDGFA, THBS1, PRKCB, and PIK3R3) were associated with HNSCC prognosis, and based on them, a prognostic risk model was developed. This evidence concerns the gene MAP2K1 and head and neck squamous cell carcinoma.