(27) showed that compared with mild rheumatoid arthritis, severe rheumatoid arthritis has higher expression levels of NF-κB (p65 and p50), BAFF, and BAFF-R in the synovial membrane, while inhibition of NF-κB can reduce the expression of BAFF-R. The gene discussed is TNFRSF13C; the disease is rheumatoid arthritis.