In GBMLGG, LGG, LAML, CESC, LUAD, KIRP, KIPAN, LIHC, MESO, PAAD, LAML, and ACC, ACTR2 acted as a risk factor, while it acted as a protective factor in KIRC and NB (Supplementary Figures 2B–F). Here, ACTR2 is linked to neuroblastoma.