RHFZD7 is a recombinant soluble peptide fragment, which can effectively target and antagonize a Wnt receptor Frizzle-7 (FZD7)(34), inhibit the activation of Wnt/β-catenin signaling pathway, and block the initiation of downstream target genes caused by β-catenin entering the nucleus, such as inhibition of c-myc, cyclin D1, survivin, and other target genes can inhibit tumor growth and drug resistance(59), while inhibition of VEGF target genes can inhibit tumor angiogenesis. Here, VEGFA is linked to neoplasm.