CXCL12 and neoplasm: DV1 peptide mainly blocks CXCR4 signal transduction by binding to CXCL12 to silence the expression of CXCR4 (36), inhibits Rho-involved RhoA/Rock/Limk signaling pathway (63), and makes Rho protein unable to regulate the tissue, focal adhesion arrangement and intracellular transport of actin stress fibers, thereby inhibiting the migration of tumor cells (64).