On the other hand, while Ighg3 showed no difference between Early and Advanced stages of arthritis (Figure 3N; Early 0.17 ± 0.16 vs Advanced 0.24 ± 0.18 counts/counts, p>0.05), Ighg3 exhibited a significant, albeit weak, correlation with talus bone volumes (Figure 3O; R2 = 0.23, p=0.046). Here, IGHG3 is linked to Arthritis.