Osteosarcoma, a prevalent kind of bone cancer, is indicated by the presence of the vimentin protein.The application of immobilized anti-vimentin antibody on the surface of the MEM-cantilever in the early identification of this tumour was proved successful (Balwir et al., 2016).Collagen type IV (COLIV) is found in the blood of individuals with colorectal, gastric, lung, liver, and breast malignancies at the same time. Here, VIM is linked to bone neoplasm.