BRCA1 is one of the genes that causes breast cancer when it is changed. It can be detected in concentrations between 10 and 100 M because of the electrochemical biosensor. Short oligonucleotides of DNA were stuck to zinc oxide nanowires that were made with the hydrothermal method and attached to a gold electrode. Differential pulse voltammetry (DPV) was used to look at how ssDNA combines with other DNA (Mansor et al., 2014). The gene discussed is BRCA1; the disease is breast carcinoma.