To assess the contribution of GR transactivation to cell proliferation, we cultured two FOXA1/GR-dependent NSCLC models, NCI-H441 and NCI-H3255, in media containing either hormone replete (FBS) or hormone-deprived (CSS) serum and stimulated these cells with either vehicle or dexamethasone. This evidence concerns the gene NR3C1 and non-small cell lung carcinoma.