In this paper, based on the mechanisms of action and targets of different anti-SARS-CoV-2 drugs, considering the efficacy and safety of various medications, it is believed that among the S pro ACE2 binding inhibitors, C135-LS/C144-LS and EKL1C show the most substantial inhibition effect on COVID-19 compared with REGN10987/REGN10933, which have entered the clinical trial. Here, ACE2 is linked to COVID-19.