On the other hand, HLA gene polymorphisms might destroy the autoimmune state, such as HLA-DQ2 and HLA-DQ8 related with celiac diseases, HLA-DRB1 related with rheumatoid arthritis, and HLA-b27 associated with spondyloarthritis (Vandenbroeck, 2012). Here, HLA-DRB1 is linked to rheumatoid arthritis.