SVBP and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Given that VASH2-GFP + SVBP overexpression in WT muscle was sufficient to model the altered myofibrillar structure that arises in the 16 weeks mdx, we posit that the increased abundance of deTyr-enriched MT arrays is an early event in dystrophic pathology that predisposes the altered myofibrillar structure in dystrophinopathies.