This report extends our previous discovery implicating deTyr-enriched MT arrays as an early event in DMD pathology that drives the excess mechanotransduction elicited Nox2-ROS and Ca2+ signals linked to dystrophic progression (Khairallah et al., 2012; Prosser et al., 2013; Kerr et al., 2015). This evidence concerns the gene CYBB and Duchenne muscular dystrophy.