Given that VASH2-GFP + SVBP overexpression in WT muscle was sufficient to model the altered myofibrillar structure that arises in the 16 weeks mdx, we posit that the increased abundance of deTyr-enriched MT arrays is an early event in dystrophic pathology that predisposes the altered myofibrillar structure in dystrophinopathies. Here, VASH2 is linked to neuromuscular disease caused by qualitative or quantitative defects of dystrophin.