Zhu et al. (2019) showed that typhaneoside can prevent AML progression by suppressing proliferation and inducing ferroptosis associated with autophagy. Furthermore, Wang et al. (2019b) found that ferroptosis mediates antitumor activities; for example, immunotherapy-activated CD8+ T cells by the combination of PD-1 blockade and CTLA-4 therapy aggravate ferroptosis-specific lipid peroxidation in tumor cells, suggesting that enhanced ferroptosis contributes to immunotherapy efficacy. The gene discussed is CD8A; the disease is acute myeloid leukemia.