Most of the genes in the HIF1A module play leukemia-promoting roles in AML, such as HIF1A (Abdul-Aziz et al., 2018), CEBPG (Jiang et al., 2021), JUN (Zhou et al., 2017), and ATF4 (Heydt et al., 2018). The gene discussed is ATF4; the disease is acute myeloid leukemia.