To further investigate the expression of these genes at the single-cell level derived from the AML microenvironment, we found that the expression of LSP1, MPO, and CRIP1 was higher in malignant cells in the GSE116256 dataset, which were consistent with aforementioned findings and previous reports (Zhao et al., 2018; Hosseini et al., 2019; Ma et al., 2020), while IL1R2 and SLC24A3 exhibited an extremely low level (Figures 6B, C). The gene discussed is LSP1; the disease is acute myeloid leukemia.