DRAM2 and age-related macular degeneration: When assessing association of DRAM2 expression to either RCVRN or BEST1 expression within each sample, we did not find significant correlation, suggesting that lower DRAM2 expression in AMD samples is not just due to photoreceptor or RPE cell loss (retina R2 = 0.28, and RPE/Choroid R2 = 0.0001).