DRAM2-associated retinopathy, also called cone-rod dystrophy 21 (CORD21), is a rare autosomal recessive IRD caused by coding variants in the DNA-damage Regulated Autophagy Modulator 2 (DRAM2) gene (El-Asrag et al., 2015; Sergouniotis et al., 2015; Birtel et al., 2018; Abad-Morales et al., 2019; Kuniyoshi et al., 2020; Krašovec et al., 2022). This evidence concerns the gene DRAM2 and Cone rod dystrophy.