Because we identified an extra mesenchymal-like cluster in DRAM2 KO organoids (Figure 2C) and because DRAM2 silencing has been associated with increased tumor growth and resistance to apoptosis (Park et al., 2009; Bai et al., 2016; Wudu et al., 2019), we wanted to know if DRAM2 loss could have consequences on cell survival, proliferation or/and migration of mesenchymal-like cells. Here, DRAM2 is linked to neoplasm.