DRAM2 and age-related macular degeneration: Since biallelic DRAM2 variants cause retinal dystrophy with early macular involvement (El-Asrag et al., 2015; Sergouniotis et al., 2015; Birtel et al., 2018; Kuniyoshi et al., 2020; Krašovec et al., 2022), and we identify lower DRAM2 expression in AMD patient eyes (Figure 1A), we decided to use DRAM2 as a case study.