To gain further insights into relevance of hPSC-retinal organoids and mouse retinas to study and model human retinal dystrophies, we compared our scRNA seq datasets generated from DRAM2 WT organoids and Dram2 wt/wt retinas to a previously published single nuclei sequencing of non-AMD human donor eyes (Orozco et al., 2020) (Figure 6A). This evidence concerns the gene DRAM2 and age-related macular degeneration.