DRAM2 and age-related macular degeneration: Using bulk RNA sequencing of macula and non-macula retinas and RPE/Choroids from human donor eyes (99 donors had no history of ocular disease and 23 donors were diagnosed with advanced AMD (Orozco et al., 2020)), we found that DRAM2 expression was slightly lower in AMD retinas and RPE/Choroids compared to non-AMD controls (p < 0.05 and p < 0.01, respectively; Figure 1A).