In humans, the cortical admixture cluster is enriched for adrenal cortical markers such as Steroidogenic Acute Regulatory Protein (STAR), CYP11B2, and CYP21A2, which could represent adrenal cortical contamination as an artifact due to impure tumor sampling or could represent a unique distinct tumor biology (9, 54, 55). Here, CYP21A2 is linked to neoplasm.