Spontaneous colitis was not observed in CDHR5∆/∆ mice (Fig EV2) but DSS and oxazolone induced significant inflammation and epithelial erosion in CDHR5+/+, CDHR5+/∆, and CDHR5∆/∆ mice (Figs 3B and C, and EV3A). This evidence concerns the gene CDHR5 and colitis.