SIRT1 and spinal cord injury: Besides, IL-16 cell clusters were found in perivascular space in sites of initial spinal cord injury (SCI).131 Ultimately, the sirtuin 1 (SIRT1) agonist, SRT1720, could significantly promote functional recovery in SCI by lowering proinflammatory cytokine levels and PVM accumulation.132 However, the study did not reveal the exact function of PVMs in the pathogenesis of SCI.