The top 20 up‐ and down‐regulated genes between malignant and mesothelial populations showed expected markers, such as PVRL4 or COL5A2, as well as genes that suggested a metabolically active cancer cell phenotype (WNT7B) and reactive mesothelial cells (MMP2 and LRP1) (Figure 4B, upper heatmap). The gene discussed is LRP1; the disease is cancer.