Recently, it has been demonstrated that H3K4me3 (an epigenetic modification to the DNA packaging protein Histone H3), which regulates α-synuclein, was significantly elevated at the SNCA promoter of the substantia nigra of PD patients observed during both punch biopsy and in NeuN (neuronal nuclear protein)-positive neuronal nuclei samples [113]. Here, SNCA is linked to Parkinson disease.