GSK3B and Parkinson disease: Interestingly, a recent investigation carried out on serum of PD patients, in brain tissues of MPTP-induced mice and in 1-methyl-4-phenylpyridinium (MPP+)-induced SH-SY5Y neuroblastoma cells has reported that cellular apoptosis could possibly be repressed by targeting the Akt-mediated GSK3β/β-catenin signalling pathway [376].