The existence of a relationship among several PD-related genes, autophagy and mitochondrial dysfunction [252], the complex interplay of mutated genes in the autophagy-lysosomal pathway and the increased risk for developing PD along with an aberrant regulation of autophagy associated with the aggregation of α-synuclein observed in PD brain tissue [253], altogether mark the importance of autophagy regulation in PD. Here, SNCA is linked to Parkinson disease.