Hyperglycemia also induces the activation of protein kinase C (PKC); notably, the PKCβ2 isoform is preferentially overexpressed, which induces cardiomyocyte hypertrophy by damaging caveolin-3 expression and insulin metabolism of Protein Kinase B (Akt)/endothelial nitric oxide synthase signaling [21]. The gene discussed is AKT1; the disease is Hyperglycemia.