CD40 and neoplasm: The activation of CD40 can upregulate VEGF, IL-6, and other factors through MAPK, PI3K/Akt, and other signal transduction pathways and then promote tumor angiogenesis by inhibiting endothelial cell apoptosis and promoting the growth of vascular endothelial cells, so as to promote the occurrence and development of cervical cancer [44, 47, 48].