SHPRH-146aa is involved in the onset of neurodegenerative diseases.321 CircZKSCAN1 encodes circZKSaa, which promotes the ubiquitination of mammalian target of rapamycin (mTOR) to suppress hepatocellular carcinoma (HCC) development.11 However, artificial circRNA is not currently being used to mimic endogenous translatable circRNA. The gene discussed is SHPRH; the disease is hepatocellular carcinoma.