MYC and chronic myelogenous leukemia, BCR-ABL1 positive: In previous studies we demonstrated that in chronic myeloid leukemia (CML) the oncogene cMYC was regulated by FBXW7 and in a similar fashion silencing of FBXW7 led to stabilization of cMYC which was toxic to the CML cells suggesting specific dosage of oncogenes may be required to drive the disease [2].