In addition, protein expression in patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and acute lymphoblastic leukemia (MOLT-4, CCRF-CEM, and RS4(11)) cell lines exhibited high level of FBXO21 compared to two independent human BM samples (Fig. 1D). This evidence concerns the gene FBXO21 and acute lymphoblastic leukemia.