In line with this, the inactivation of the Abelson (ABL) murine leukaemia viral oncogene homolog (ABL1), upregulated in HLRCC tumours by inhibition of the protein-tyrosine phosphatase N12 PTPN12 [83], led to the suppression of mTOR-mediated HIF1α translation. This evidence concerns the gene ABL1 and hereditary leiomyomatosis and renal cell cancer.