Immunofluorescent staining was next performed to investigate whether CD38 expression levels were regulated by IRX4647 or anti-PD-L1 treatment in subcutaneous syngeneic 344SQ lung cancer cells present in mice treated with vehicle, IRX4647, anti-PD-L1, or the combined regimen, as shown in Fig. 5a. This evidence concerns the gene CD38 and lung cancer.