Five predictive factors, including age (HR, 2.615; 95% CI 1.433–4.773), tumor number (HR, 1.532; 95% CI 1.074–2.185), postoperative AFP level (for 25–400 vs. ≤ 25, HR, 2.597; 95% CI 1.589–4.246; for ≥ 400 vs. ≤ 25, HR, 3.222; 95% CI 1.683–6.167), postoperative protein induced by vitamin K absence or antagonist-II (PIVKA-II) level (HR, 1.739; 95% CI 1.166–2.593), and ECOG PS (HR, 1.523; 95% CI 1.026–2.261), were adopted in the final model. The gene discussed is AFP; the disease is neoplasm.