For example, a case of a 50-year-old patient with a solitary tumor, MVI grade 1, preoperative AFP ≥ 400 ng/mL, preoperative CA19-9 > 35 U/mL, and ECOG PS equal to 0 would score a total of 320 points (40 points for age, 0 points for tumor number, 82.5 points for MVI, 97.5 points for preoperative AFP, 100 points for preoperative CA19-9, and 0 points for ECOG PS), for a probability of recurrence of 85%. This evidence concerns the gene AFP and neoplasm.