EZH2 and neoplasm: Besides, inhibiting the transcription of many genes, EZH2 has also been presented to suppress the expression of many tumor suppressor microRNAs (miRNAs), such as miR-125a, miR-125b, miR-138-5p, and miR-320c in HCC, thus assisting HCC tumorigenicity and metastasis [24–27].