HMGA2 can effectively adjust EMT through the PI3K/AKT, MAPK/ERK, TGFB/Smad, NFrB, and STAT3 signaling pathways, enabling HCC cells to invade local tissues, get the penetrating ability of intravascular, and give birth to offspring with the tumor-initiating ability [53]. Here, TGFB1 is linked to neoplasm.