CD4 and neoplasm: Furthermore, tumor infiltrating CD4+ T cells in the TILs/neratinib group showed higher GrzB expression level than that in the TILs monotherapy group (Fig. 7c), which is further supported by the impressive CD4+GrzB+ T cells in the microscopy images of TILs/neratinib group (Fig. 7d), despite the comparable T-cell infiltration between the two TIL containing groups (Additional file 1: Fig. S7e).