Wide-ranging mutations have been described in ALS, including superoxide dismutase 1 (SOD1) gene encoding the Cu, Zn superoxide dismutase 1 [102, 103], C9ORF72 gene encoding C9 protein [104], CHCHD10 gene encoding Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 protein (C10), or protein N27C7-4 [105], TARDBP gene encoding TDP-43 protein [106], FUS gene encoding RNA binding protein Fused in Sarcoma (FUS), and OPTN gene encoding optineurin protein [107], among others. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.